研发创新
R&d innovation
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Construction of chlorogenic acid-containing liposomes with prolonged antitumor immunity based on T cell regulation
Construction of chlorogenic acid-containing liposomes with prolonged antitumor immunity based on T cell regulation2020.09.30本研究以绿原酸-磷脂复合物（PC）作为药物中间体，成功制备了含有绿原酸-磷脂复合物的聚乙二醇化脂质体（CHA-PCPEG-Lipo，简称CPPL），旨在降低给药频率并提高治疗效果。与绿原酸溶液及负载绿原酸-磷脂复合物的普通脂质体（CHA-PCLipo，简称CPL）相比，CPPL表现出更优异的理化性质，显著增强了药物在肿瘤部位的蓄积能力。 -
Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma
Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma2020.05.10本研究开发了一种甘露糖修饰的脂质体，用于靶向递送绿原酸，以促进肿瘤相关巨噬细胞（TAMs）的极化，从而有效治疗胶质母细胞瘤（GBM）。研究发现，甘露糖修饰的脂质体能够将绿原酸靶向递送至TAMs，通过激活STAT1并抑制STAT6的活性，促进TAMs从促肿瘤的M2表型向抗肿瘤的M1表型极化。
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绿原酸的药理作用及机制研究进展
绿原酸的药理作用及机制研究进展2020.04.29绿原酸是一种广泛存在于植物中的水溶性酚类化合物，具有多种药理作用和潜在的应用价值。近年来，其在抗氧化、抗炎、抗菌、抗病毒、调节代谢等方面的研究取得了显著进展。绿原酸通过激活SIRT1和AMPK/PGC-1信号通路，调节线粒体功能，减少氧化应激和细胞凋亡等发挥抗炎作用。
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Chlorogenic acid inhibits esophageal squamous cell carcinoma growth in vitro and in vivo by downregulating the expression of BMI1 and SOX2
Chlorogenic acid inhibits esophageal squamous cell carcinoma growth in vitro and in vivo by downregulating the expression of BMI1 and SOX22019.10.26本研究探讨了绿原酸对食管鳞状细胞癌（Esophageal Squamous Cell Carcinoma, ESCC）的抑制作用及其分子机制。研究通过体外细胞实验和体内动物模型实验，证实了绿原酸能够显著抑制ESCC的生长。在体外实验中，绿原酸处理的ESCC细胞表现出增殖抑制、迁移和侵袭能力下降。此外，绿原酸通过下调BMI1和SOX2的表达，抑制了ESCC细胞的自我更新能力。
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Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation
Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation2019.09.22绿原酸可能是一种安全有效的癌症分化诱导剂。通过“教育”癌细胞分化而非杀死它们，可能是一种新的癌症治疗策略。绿原酸在复发的高级别胶质瘤患者的I期临床试验中表现出色，已被中国食品药品监督管理局（CFDA）批准进行Ⅱ期临床试验。
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Development of an LC-MS/MS method for quantitative analysis of Chlorogenic acid in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor
Development of an LC-MS/MS method for quantitative analysis of Chlorogenic acid in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor2019.08.14本研究开发了一种基于液相色谱-串联质谱（LC-MS/MS）的定量分析方法，用于检测人血浆中的绿原酸，并将其应用于晚期实体瘤患者的药代动力学研究。