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Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice
Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice2025.03.03该论文研究了绿原酸通过抑制细胞衰老和预防小鼠皮肤光老化中的作用，并确定了其作用的蛋白靶点为烯醇化酶1（ENO1）。 -
ScRNA-seq unveils the functional characteristics of glioma-associated macrophages and the regulatory effects of chlorogenic acid on the immune microenvironment-a study based on mouse models and clinical practice
ScRNA-seq unveils the functional characteristics of glioma-associated macrophages and the regulatory effects of chlorogenic acid on the immune microenvironment-a study based on mouse models and clinical practice2025.01.10这篇论文研究了绿原酸（Chlorogenic Acid, CHA）对胶质瘤（Glioma）免疫微环境的调节作用，以及其在小鼠模型和临床实践中的潜在应用。研究通过单细胞RNA测序（scRNA-seq）揭示了胶质瘤相关巨噬细胞（Tumor-Associated Macrophages, TAMs）的亚群和功能特征，并探讨了CHA对免疫微环境的调节作用及其临床应用潜力。
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Target fishing and mechanistic insights of the natural anticancer drug candidate chlorogenic acid
Target fishing and mechanistic insights of the natural anticancer drug candidate chlorogenic acid2024.07.10该研究通过开发绿原酸光亲和探针结合前沿的化学生物学技术，深入揭示了线粒体乙酰辅酶A乙酰基转移酶1（ACAT1）作为绿原酸关键靶蛋白的重要角色。研究团队综合运用了组学、分子生物学、细胞生物学和结构生物学等多学科技术手段，对绿原酸与ACAT1的相互作用机制进行了全面而系统地研究，为绿原酸在癌症治疗领域的临床应用奠定了理论与实验基础。
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ACAT1 Induces the Differentiation of Glioblastoma Cells by Rewiring Choline Metabolism
ACAT1 Induces the Differentiation of Glioblastoma Cells by Rewiring Choline Metabolism2024.01.05绿原酸作为一种天然小分子化合物，通过抑制ACAT1的磷酸化，能够有效诱导GBM细胞的分化，具有作为胶质瘤治疗药物的潜力。
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Cancer Differentiation Inducer Chlorogenic Acid Suppresses PD-L1 Expression and Boosts Antitumor Immunity of PD-1 Antibody
Cancer Differentiation Inducer Chlorogenic Acid Suppresses PD-L1 Expression and Boosts Antitumor Immunity of PD-1 Antibody2024.01.04该研究聚焦于绿原酸（CHA）在癌症免疫治疗中的作用，发现CHA可作为小分子免疫检查点抑制剂，通过诱导分化，抑制癌细胞上PD-L1的表达，有效促进肿瘤中浸润T细胞，增强抗PD-1抗体的抗肿瘤效果，有望成为与抗PD-1抗体联合使用、增强抗癌免疫治疗效果的有潜力药物。
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Chlorogenic Acid Induced Neuroblastoma Cells Differentiation via the ACAT1-TPK1-PDH Pathway
Chlorogenic Acid Induced Neuroblastoma Cells Differentiation via the ACAT1-TPK1-PDH Pathway2023.06.14本研究揭示了绿原酸通过ACAT1-TPK1-PDH途径诱导神经母细胞瘤细胞分化的机制。研究发现，绿原酸在体内外均能诱导神经母细胞瘤细胞系（如Be(2)-M17和SH-SY5Y）的分化。其机制涉及抑制线粒体乙酰辅酶A乙酰转移酶（ACAT1）的活性。ACAT1的敲低或抑制可上调硫胺素焦磷酸激酶1（TPK1）的表达，进而激活硫胺素代谢途径，增强丙酮酸脱氢酶（PDH）的活性。